A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain

Abstract

A simple and direct method of labelling brain norepinephrine stores, via injection into the lateral ventricle is described. H3-norepinephrine introduced by this procedure was found to be distributed evenly in both sides of the brain. The accumulation of H3-norepinephrine in various brain regions parallels that of endogenous levels of norepinephrine and the amine is selectively localized in the "nerve endings". The disappearance of H3-norepinephrine administered by the direct injection technique and its modification by drugs are similar to that of material introduced by stereotaxic procedures. © 1967.