Statins and other lipid lowering drugs have been repeatedly described to decrease blood levels of minor fat soluble components such as vitamin E (as α-tocopherol). Clinical consequences of this secondary state of deficiency have not been described so far, but recent biochemical and molecular evidence on homeostatic and molecular responses to vitamin E deficiency in skeletal muscle cells may suggest the hypothesis presented in this paper of a role as risk factor in the development of statin-associated myopathy. This hypothesis that needs to be further investigated, could suggest the need for precautionary measures during lipid lowering therapy, which include timely diagnosis and active prevention of vitamin E deficiency. © 2009 Elsevier Ltd. All rights reserved.
CITATION STYLE
Galli, F., & Iuliano, L. (2010). Do statins cause myopathy by lowering vitamin E levels? Medical Hypotheses, 74(4), 707–709. https://doi.org/10.1016/j.mehy.2009.10.031
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