Abstract
Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.
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CITATION STYLE
APA
Sobell, H. M. (1985). Actinomycin and DNA transcription. Proceedings of the National Academy of Sciences of the United States of America, 82(16), 5328–5331. https://doi.org/10.1073/pnas.82.16.5328
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