Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system

Abstract

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and collateral formation, stroke, and heart failure. In this review, we discuss in detail the biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4, and 5), their roles in cardiovascular cell biology, and their contributions to disease development. © 2012 American Heart Association, Inc.