Abstract
Imidazo[1,2-a]pyrimidines are GABAA receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimize this functional selectivity are described. © 2006 Elsevier Ltd. All rights reserved.
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Blackaby, W. P., Atack, J. R., Bromidge, F., Castro, J. L., Goodacre, S. C., Hallett, D. J., … Wafford, K. A. (2006). Imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. Bioorganic and Medicinal Chemistry Letters, 16(5), 1175–1179. https://doi.org/10.1016/j.bmcl.2005.11.112
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