Rearranged limonoids from Khaya senegalensis

Abstract

The stems of Khaya senegalensis yielded three limonoids which appear to be novel. These compounds were identified on the basis of spectroscopic analysis as methyl 1α,6,8α,14β,30β-pentahydroxy-3-oxo- [3.3.110,2.11,4]-tricyclomeliac-7-oate; methyl 1α,2β,3α,6,8α,14β- hexahydroxy-[4.2.110,30.11,4]-tricyclomeliac-7-oate and methyl 1α- acetoxy-2β,3α,6,8α,14β-pentahydroxy-[4.2.110,30.11,4]- tricyclomeliac-7-oate. The two latter ones represent a novel group of methyl tricyclomeliac-7-oates. Scopoletin, scoparon, sitosterol, stigmasterol, Campesterol and 3β-O-β-D-glucopyranosylsitosterol were also isolated.