Scattering-based cytometric detection using integrated arrayed waveguides with microfluidics

Abstract

Scattering-based on-chip excitation and detection on the arrayed-waveguide platform has been developed and implemented. Detected signals were processed with the proposed multiplication-based cross-correlation algorithm. The algorithm is capable of not only achieving signal enhancement (80 dB relative to the untreated signals) but also velocity measurement. Thus, particles flowing at different speed could also be accurately detected. Processed signals were verified by comparison to frame-by-frame video images, showing excellent correspondence. The signal processing algorithm can be easily extended to real-time on-chip detection. © 2007 IEEE.