Papers

DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for high-throughput data collection. Over the past three years, massively parallel DNA sequencing platforms have become widely available,…

Ten years after the publication of the position paper The hallmarks of cancer (Hanahan and Weinberg Cell 100:5770, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

The two most commonly used methods to analyze data from real-time, quantitative PCR experiments are absolute quantification and relative quantification. Absolute quantification determines the input copy number, usually by relating the PCR signal to…

Use of the real-time polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Real-time PCR is easy to perform,…

RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies. Studies using this method have already altered our view of the extent and complexity of eukaryotic transcriptomes. RNA-Seq also provides a…

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include…

In this article, we attempt to distinguish between the properties of moderator and mediator variables at a number of levels. First, we seek to make theorists and researchers aware of the importance of not using the terms moderator and mediator…

Error bars commonly appear in figures in publications, but experimental biologists are often unsure how they should be used and interpreted. In this article we illustrate some basic features of error bars and explain how they can help communicate…

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of…

We describe a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations. We assume a model in which there are K populations (where K may be unknown), each of which is…

Insights into conducting research and the writing of scientific papers are given by Prof. Whitesides in this short essay. The manuscript and its guidelines has been circulated within the Whitesides' research group since 1989.

We are developing a dual panel breast-dedicated PET system using LSO scintillators coupled to position sensitive avalanche photodiodes (PSAPD). The charge output is amplified and read using NOVA RENA-3 ASICs. This paper shows that the coincidence…

Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.

There is now ample evidence of the ecological impacts of recent climate change, from polar terrestrial to tropical marine environments. The responses of both flora and fauna span an array of ecosystems and organizational hierarchies, from the…

The dynamic capabilities framework analyzes the sources and methods of wealth creation and capture by private enterprise firms operating in environments of rapid technological change. The competitive advantage of firms is seen as resting on…

Computing as you know it is about to change, your applications and documents are going to move from the desktop into the cloud. I'm talking about cloud computing, where applications and files are hosted on a "cloud" consisting of thousands of…

We have designed and implemented the Google File System, a scalable distributed file system for large distributed data-intensive applications. It provides fault tolerance while running on inexpensive commodity hardware, and it delivers high…

Provided certain obstacles are overcome, we believe Cloud Computing has the potential to transform a large part of the IT industry, making software even more attractive as a service and shaping the way IT hardware is designed and purchased.…

We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides…

1 1 Sign Up The 2013 Australian Defense White Paper (DWP) has left pundits scratching their heads rather than their favorite itch-could it really be that 'the China threat' is more puff and magic than an actual dragon at the doorstep? Abstraction…

Yesterday, the White House announced that President Obama will meet with Chinas President Xi Jinping on June 7-8 in California. The announcement said that the two will hold in-depth discussions on a wide range of bilateral, regional and global…

Are you a liberal imperialist? Liberal imperialists are like kinder, gentler neoconservatives: Like neocons, they believe it's America's responsibility to right political and humanitarian wrongs around the world, and they're comfortable with the…

Yesterday, the White House announced that President Obama will meet with Chinas President Xi Jinping on June 7-8 in California. The announcement said that the two will hold in-depth discussions on a wide range of bilateral, regional and global…

1 1 Sign Up The 2013 Australian Defense White Paper (DWP) has left pundits scratching their heads rather than their favorite itch-could it really be that 'the China threat' is more puff and magic than an actual dragon at the doorstep? Abstraction…

Yesterday, the White House announced that President Obama will meet with Chinas President Xi Jinping on June 7-8 in California. The announcement said that the two will hold in-depth discussions on a wide range of bilateral, regional and global…

We describe a scaling method for templating digital radiographs using conventional acetate templates independent of template magnification without the need for a calibration marker. The mean magnification factor for the radiology department was…

Naphazoline nitrate, oxymetazoline hydrochloride, antazoline hydrochloride, xylometazoline hydrochloride, tetramisole hydrochloride, chlorpheniramine maleate, adiphenine hydrochloride, amitriptyline hydrochloride and procyclidine hydrochloride were…

Solutions of the hydrochlorides of antazoline, tolazoline and xylometazoline, and of naphazoline nitrate in H2O (at concn. of 0.1 g of base per 20 ml) were made alkaline with dil. aq. NH3 and extracted with CHCl3. After dilution of the extracts with…

Naphazoline nitrate, oxymetazoline hydrochloride, antazoline hydrochloride, xylometazoline hydrochloride, tetramisole hydrochloride, chlorpheniramine maleate, adiphenine hydrochloride, amitriptyline hydrochloride and procyclidine hydrochloride were…

IR spectroscopy has been widely employed to distinguish between different crystal forms such as polymorphs, clathrates, hydrates and co-crystals. IR has been used to monitor co-crystal formation and single synthon detection. In this work, we have…

Three halogen bonded co-crystals between tetraphenylethylene derivatives with peripheral pyridine groups and 1,4- or 1,2-diiodotetrafluorobenzene have been characterized. Two crystalline networks prepared from 3-pyridyl-substituted…

Background Regulation of cellular events is, often, initiated via extracellular signaling. Extracellular signaling occurs when a circulating ligand interacts with one or more membrane-bound receptors. Identification of receptor-ligand pairs is thus…

Goudie discusses Herman Melville's "Typee." Clothing and fashion have an important place in the novel because they create a parallel discourse through which the reader can follow Tommo's difficulties with signification and his own placement within…

Selecting and implementing a learning management system (LMS) is an important task for many higher education institutions, which can consult various resources1 when embarking on such endeavors. Educational technology practitioners regularly discuss…

Library and information professionals always play crucial role to make the users informed and knowledgeable and to support the teaching, research and institutional programmess. Today Librarians are experimenting new methodology of learning with…

This paper summarizes a qualitative meta-analysis of the empirical research on the effectiveness of teacher induction programs over the last decade for the purpose of identifying the essential elements that make them effective in reducing teacher…

This article describes a research on improvements resulting from the implementation of electronic ticketing system in two cities and a metropolitan region of Rio Grande do Sul. This study was designed to identify whether such improvements are…

The design of railway sleepers must account for irregularities of the train or the rails that generate dynamic loads. The sleepers could develop cracks during a train passage although not influential enough to disturb immediately the global track…

The design of railway sleepers must account for irregularities of the train or the rails that generate dynamic loads. The sleepers could develop cracks during a train passage although not influential enough to disturb immediately the global track…