Abstract
This work presents a high sensitivity biosensing platform for quantitative proteomics. Biomolecules labeled with magnetic nanoparticle (MNP) tags are quantitatively sensed by a high density array of 256 giant magnetoresistive spin-valve (GMR SV) sensors connected to a 0.18 μm CMOS sensor interface featuring 16 ΣΔ modulators with 84 dB dynamic range. The performance of the system is demonstrated through detection of a spiked tumor biomarker, epithelial cell adhesion molecule (EpCAM), at concentrations below 10 picomolar (pM). © 2011 JSAP (Japan Society of Applied Physi.
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CITATION STYLE
Hall, D. A., Gaster, R. S., Osterfeld, S. J., Makinwa, K., Wang, S. X., & Murmann, B. (2011). A 256 channel magnetoresistive biosensor microarray for quantitative proteomics. In IEEE Symposium on VLSI Circuits, Digest of Technical Papers (pp. 174–175). Institute of Electrical and Electronics Engineers Inc.
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