On the effect of melatonin upon human brain. Its possible therapeutic implications

Abstract

Various doses of melatonin were administered to normal and epileptic subjects. Increase of EEG alpha activity, sleep, imagery, and a feeling of well-being and elation were found. A decrease in paroxistic grapho-elements of the epileptic patients was also noticed. When two parkinsonians received 1.2 g of melatonin orally for four weeks, a striking improvement in the symptoms and signs of the disease was detected. © 1971.