Fast multidimensional NMR spectroscopy using compressed sensing

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Abstract

Make it snappy! The use of compressed sensing to reconstruct multidimensional NMR spectra enables significant reductions in recording time. Thus, 3D HNCA (blue) and HN(CO)CA spectra (green) of sufficient quality for rapid protein-backbone assignment were reconstructed from only 16% of the fully sampled data. The generality of the method and its robustness to noise should make it more broadly applicable, for example, to solid-state NMR spectroscopy. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Holland, D. J., Bostock, M. J., Gladden, L. F., & Nietlispach, D. (2011). Fast multidimensional NMR spectroscopy using compressed sensing. Angewandte Chemie - International Edition, 50(29), 6548–6551. https://doi.org/10.1002/anie.201100440

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