Influence of nanostructure morphology on host capacity and kinetics of guest release

Abstract

Morphology-dependent drug loading capacities and release kinetics are observed from pH-responsive diblock copolymer-based nano-objects, derived from the same block copolymer precursor. Shell-crosslinked, rod-shaped nanostructures exhibit a higher doxorubicin-loading capacity and rate of release than do their spherical counterparts. The extent of crosslinking and the type of crosslinker is also demonstrated to affect the rate of release. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.