Intercalation behavior of 5-fluorouracil into Mg-Al layered double hydroxide.

Abstract

As described in this paper, the intercalation behavior of 5-fluorouracil (5-FU) into Mg-Al layered double hydroxide (LDH) was investigated using copptn. and ion-exchange methods. Actually, 5-FU/LDH has been characterized using element chem. anal., powder X-ray diffraction, FT-IR spectroscopy, thermal anal. and SEM. Intercalation of 5-FU was achieved using both methods; the amt. and orientation of 5-FU intercalated differed considerably by the intercalation method and co-existed anion. The d-value of 5-FU/LDH expanded to d003 = 0.80-1.10 nm, suggesting that 5-FU was intercalated into the LDH interlayer space. Results of the thermal anal. showed that the thermal stability of 5-FU was improved by intercalation in the LDH interlayer space. We propose LDH as a good host material for storage and carriage of drugs. [on SciFinder(R)]