Sign up & Download
Sign in

Interventions to facilitate adherence

by R Horne, I Kellar

Cite this document (BETA)

Available from Ian Kellar's profile on Mendeley.
Page 1
hidden

Interventions to facilitate adherence


 



















































































 

 












 














!

 "
#$$%


 
 
 
        
    
! 
"  #$ % &
 
'( 
)"  #  &
 
 *
)"  
"  
 )  #
  +  
+ + 
,  "
 )  #$ % 
&
 
  
 
 -
 
" . #"  

*
  #$ % &
 / 01
,! $ #  2#   
  #   / 3
 

.
 1
.

  
 
"  
     
   #2 # '45"
*- 6 7 6 6
(
 849:;3<;5=02 >849:;3<;5=3
Page 2
hidden

 











































































































 
) :!     

 
2B8L##
/&

   
       
 

  J>   
  ( 
6+ 
   
  >  
  
 
   
  
  
 6& 
    
 498   
 



 
 

    
 
  45:96  
  


       /   #+$ 
$ #4553J
 #455=J+, 
#@ 
   #9889J"  # ( #

2 #988;1 
      /   #
+, 
#@ 
+  
#988916
.        >   
#  
  

 
      /455=1#"  
/988;1#
     
 
 /988916
  (    

 
    
  >         

 #   #> #   ( 

    
 

      

/,+ #)
 #  
B
 #455;1#


/,+ #&
 #98881
    /,+ #
988<16
.  
  > #>

  
 
  
     D
 #

  
   





 
   
6 
 
 

  %    
    

        6# 

>   
  
  



 /

  
1
 
    

 
  
 6


  
>

   
    6
'

 
5
5 

5

5 

"&$!
!$12$5
 /455=1
 
 *  -  ( 
   

      
 
 
 
 6

 (>
 
 

  
   


  -  
 
 /
  -  

  
  16
Page 3
hidden

 











































































































 
! 
   
   

  /   

 
1
  

#
   F
   6

 

 
409 
 

 45:5

455<6

   

 

  
3 4+)#:<-    #   

H

   6
3 $
)#:,##<?    %  
 
A   % ( 
   



 ( 

  (   

  

 
 6
3 ':#<?     
 
   
  
   
6
3 ;+)"":#3)+1? 


  
 
    #


   #
  
    6
B409     
#489    
   6B #08 
 J<;
  J

J

   608    
 

 
  
 6B #;9
  

 
 J4; #
  
 
 J


#
  G 
    6! 
 
        
    

 
 #      > 
 
     98 


 6#



  
 
   
 #
    
       
    

6!

# F 
 
 
      
 
  6@  ## /455=1 

 M 
        
       
]  

    6%
  
    
 
  
 



          
    (

 

 6
$&$!-"+
!$12$5
    -         

  
 #
 

  
 

 

     F   /"   #
988;16
 
50 
 34  
 

 45:4
98886!   

   6
3 4+)#:<? 
    #
   
H

   6
3 $
)#:,##<? 
  
  
   
  

 # 

(

 #
  
 6
3 +? >
   6
B50
 
#<4 
 J99
  J
;9
 
   6!   
    6
/455=1#     

     
Page 4
hidden

 











































































































 
 
 
 /<44 1#
   # 
        
  #
>   
   

   

 6

 
  
  
      6#  
 

 M    
    

  # 
 #
 

 6%6
'<+$-
!$12$5
) "   /988;1#    /98891

>

      
 
  
# -

  

  # 
  
 
 
   6
)
 >

-
    >  #
  
  
6
    

 4<0  
 #
 ;0  
 

/45:9-98841#
 -
#

    #
  -   

     >
 6>  
 

      
 #   
         /49 
 1#
 
/ 
 1# - 
   / 
 1#

 
/
 
 16#    - 
  

6
  
    A>   
 
  -
      

  

 
 
6%
* 
 
    
  -
 6
+#  D
   A
   (#%
 
  
    6
<-&$('&2%
!$12$5
8",,"52+/
'<+$-
$&
',7@
FF



 

& 
 
5

    /98891


 
 
 A



6%      
  >
 

   
  #   
 
  
 
 
 
  # 
 
 
 

   
 /455=16+#>
  
 > 

#
 

    
 
 -
   # 
 
         
 
 

 
 "   
/988;1 
6 D
 #  (  
A
 

%
    
    #  



 98896
   >

 
 

  
  


 6  #    #  #     

    /


1     
Page 5
hidden

 











































































































 

 #
 D
6#   

  
 
     
 
 
 6
*>
     (   
 



 
  
  
64;
1


>
    /98891 
 
  
 

    
 



     

6
3 

>

    /98891    

   


   

6
 
 
    

   
 
 


A  

%>
 / .
>016
+# 


>
 
  


 
    #     
  
   #     
   
 
  #       
6
.

 #
 
    #
  

*   
  6.  
# 
  
/    #98891>

64<




   


      
3 ;")#:#<?   
   
  ( 
# # 
 #   

H

   6
3 ;#:"+)1?   
 
   
 # 
 (

 #
    #
  
 6
+? >
   6







     
    

( 
6+       6)
   
 


4;B
>

 
   
   >
 
> -
6!

 

 >
  
 

 -

    >     
 
  

  

 
( 
 
 
 #   -6! 
  -
-
 
  
 


         
 6 

 

        
 
  


#  
 
 6! 

           

  
 
  
( 
 6
4<
 
 

! $    $" #
 "  
' 6
Page 6
hidden

 











































































































  
  
A
  6%# 
    
 

  
D

  
   

6!     
    
#

( 
?      
      6
.       ( 
  
 
 #
      
 
     
 
  6


      
   6 
  

  
      


 (     /( 
# 
1
          
   ( 
 
   6
&

 
& 
5


 

 
;8   

    
/9889140

 
98 
   
 

  
   
  / .
>3

   
 
16)
 D
 #  08  

6
2
4
   (
  

 
     


/
 


 
1#     
/

 

  /# #( 
1
    /#   
   1

 
 
  1#
   


 
  /
16
B 
 
#98( 
  #   

    #
94 
   / 2
4#;16! 
 #;3

          
 - 



/ 2
4#916B;3
 

   #4;

 

  #: 
  
  #
43
 
  
  / 2
4#;16B


 
 
 #:
#9  #
0
 
   / 2
4#;16   
       

 /- D
O6=4=#
O633<1#
   # #    
 


 
  6# 9- 
#F- >  
 
 
  
 
 




 
 
       /U8688016
# 

      

 
    (
 
6
 


402   

     9889>


),B

A   % 
  
  
  6
Page 7
hidden




































































































































































































































































)






























,


H
"







2
/.
!$

7

$-
.,
&-
"
8
&6
$
'.
/(
$+
&$
3
!$
12
$5








4









7



;
)








M-

9
B










;
B



 
4








7



9
B










4
B




9








7



4
B




9












4
B










9
B




4
)





;









7



;
)





4








7



4
B












9
)












;
)











4
B




9









7



4
B




9








7



4








7



4
)













4
B







7



4
B











4
B
















4
B




4 





F






Page 8
hidden

 











































































































  
& 

 

 
5

. -   
      
 
 
  /455=1#"   /988;1#
    
/98891 
 
 

 6B40; 
  


 /455=1#
98 

"  #   

   

 
6  

  #   

 >
  -
 
   
   


 
  6B34 
 
"  #

    /98891
45 

 


 
6  
 

D


    /98891     /U98Y1

 -
/T3  1  
  -   6

  ),B
 
      

  /455=1#"   /988;1
   
 /98891J    
  

 
6.


 
  -   # F 

 
      
 

 
 -   "   /988;1

    
  

  <
44 #
 
/455=1

  6!   


  
   
#  
 
 6
  

 

      % M>    

  -
      
  

 
 
%/    6#
988916
B

 
 
 (      
   
   


 
6 

  

2(2&'&2"+-
"8
'36$!$+%$
2+&$!1$+&2"+-
!$-$'!%6
2 
 
#      
  
   
 
     


     6  (   

  

   
6


 G )+      
 
 6    
  


  
 6  

 


    
  
  

  


  
 
 #  
  

    -
   
  /
 
 1#
  
 

   
 (  
 
 > 6.
   
 
    #   (


  

 
     
 6
!    (  

 

  /# 
 
 

     %
    
     (  

   


16
Page 9
hidden

 











































































































 
 5@3H##1""
2   


 
 
A  - 
6% 


    
 
  

   6





 0#)"

)
  
 

        #
 

     (


 (6 
  
       >/
   

 #
     #   16
 5$#,361#)+  
    >
   

  
      
   6 D
 #  
   
  

      
D

6
 /,
# ,2     

 
  
 6! 
 
+3
      
 
 

 
6  
   


 ( 
    
      
  > /#
   #
   


 
 16
 /#"#)    
  

     
#
 
  

#D
  
 
 
    
   >  
6) #
>     
  
 

6

     

 
     


 
#    
   ( 
 #        #
 
6   
 
 > 4-;6* > 
   / 
 
#

 
1 
      
 
   
   
 
    /  
 

  1#
  /#( 
# #1

 
 
   

    
 
6











Page 10
hidden

 











































































































 
")
0
+&$!1$+&2"+-
'33!$--2+/
*!'%&2%',
A'!!2$!-
B,2(2&'&2"+-
2+
%'*'%2&<
'+3
!$-".!%$-D

.%%$--8.,
/& (#   
2 (#45:<1
  
 
  
         
    
 >    6
"    @
4/ 1
    

 
  

 J   
  %
 

 
 6@
9   
    


 
  
  
 
 
 


     6! 
 
     ( 
 

 
 
   

(
 
 ( 6@
;   
<8

  ( 

     48  
  / 
   
16"    @
<
 A L!,)-" (%/   


 - (
A
  %  
  

   ( 16.A   %   


    

 
  
  

  
    6
.
 
          

  
 
6
+-.%%$--8.,/( #45=31
 
 
 
  


 
        
 98
=8  6
"     

   

   
   /       
 


 #
 #
  
 
 #
  %  1#     
>  

 
       (  
 6 (  
 
    ( 
        
  ( # 
  

(

  

    ( 6
'   
  

 >  

 
    - 
 
 6
Page 11
hidden

 











































































































 
")
0
+&$!1$+&2"+-
'33!$--2+/
*$!%$*&.',
8'%&"!-
2+8,.$+%2+/
("&21'&2"+
.%%$--8.,
/2
  #45531
  
 
  
   
  6
"       38  
6
"     
 




  #
     


 
- 

    

 


  6 -
& (

/&1          
     6"    
&(
 -



 #( 


 
 
   

   
 6! 


 D
      #&


  

  
 
  
 6

 
 
   
  
 

4:6:    
 
446: 
  /"O868;16
+-.%%$--8.,/  6#45=:1
 
 
 
  
      
 
 4=  

   
 F  
F 
 
# 
 ,)+-!!! 6.   

   
     6
"   
 
  

 /41  
 


  
 
    
 
 #/91
 
  
  

  
 

    
 
 #/;1  
 
 >
 

   #
/<1 
  
 
 >


   6E  
 

 
   


  # 
 #
 
# 

 
    6   
 


  
     
 6
+ 
 
       
  
 
   >
 
   


 
   6
'  
  
  

6


Page 15
hidden

 











































































































 
$--"+-
8"!
&6$
%"+&$+&
"8
2+&$!1$+&2"+-
!  9#  
 
 
  


  
    6  
  

  
   
    
   

> 
  6
     
  

 
    

 
         
    
 6!   

   

 
   # 
 

>    
    %   
  
   6
A  %   
    
   

 
A> %   #
 D

  
   
  
/ 
 

  ;1

   
 
 /#  #

# 
   1#  
  
 > /#   
 
  
  

 
  <16    
 
 2
96
   
     
 
     
   
   
    

 
   
   
  
(    
    

 
 
6
,       


 
 
   
     

6!    


    
4 !       

  6
9 +     
   -
(

  C?  
- 
 6
;   
- 
 #    

6
Page 16
hidden

 











































































































  

Page 17
hidden


















































































































































































."
"
.!
).
&
.


























>





-,




(C
!










C
"









)

































!'
*
'
!B
'
B

.
$*

+
*,
!
.
!B
'
.,
*
*
'
*
)



















-











"

























-"















-)






-"















-"














-+





-







-,
>




-B





!'
*
'
.&
2
.
B
)

*\
*
'
.&
/*
'E
!
B'
+
*'
.
&1
2
.
B
)

-!














-)










-)






-







/










 #





6
1


-+






-2








-



















-









-+







-


"











-E















2
/.
!$

7


'*
"
8
3$
&$
!(
2+
'+
&-
"
8
'3
6$
!$
+%
$

Page 18
hidden

 











































































































  
!    

    
4 !    
 

  
 
  
    6   
 
  
   (

 
    
    / 

     16
9 !   
   62> #  
 
     /#
 
 

     1#   
  -
   /#*>"   J
HH6>   6  6
(H1  


6
; B    
  
  
  


 A
  -  %
      
   
   6
< "
     #
 
 -

   
 
     (      ( 6


 

" &
 

 

     > 
      
    

     
      (

 6
 


 
A  % 
 


 
6  
   A  -  %

 # 
  - 
    #
 
 
 / .
>:16B   
     
>           -
      
 
/ 
.
>=16
.
 
           
>  
   
 
 
  6
  (D
      
    
  


   
  
  
     >  
#
 
  6)    D

   
 ')
$  #   
  



     

 
   62 
"      

 
  /HH6 
    66
(H16
**,<2+/
&6$

8!'($5"!4
8"!
%"(*,$)
2+&$!1$+&2"+-
&"
'36$!$+%$
!       

      
 
 
  

     
  (

6    
      #

    

#  
   A 

 %6

 
 
   
  
 

 
-

   6#
-    
> 
-
 6  # 
 (   
    
Page 23
hidden

 










































































































(#&.#@ F#$#)#*#+ ##V #)&
$ #$.645=36
M.
F
    (    

  %#&)#0#;99/<1;0:-34
 #)# #@
   #,645=:6M.   
 
   
 
   %( 
#

 #
 %#2"#+);

;=00-38

#&# 
& #+.# #*# (#
  #B6455=6
*   
       
 
     
 
  6
'#

)0:/;14<3-04
 #+#2F (##   #.#$  #.&#)
(#"#
) #, 698886M2 (
  
 
 
>    %#$
%+#&)#
;9435<-3
,+ #+6988<6M) 

  
 
 
  . -   %2#
;
#-9;/9198:-4=
,+ #+#&#)
 # 698886M,     (
    
   + -   
  >

     
 %#
'
8#%+438/4<19484-:
,+ #+#)
 #,#  #,
B
 #&6455;6
M"  %     
    %
 
 
  
 
 
  
%#2#

;
#-49/915;
*#.# #'
 #698806M -  

 -      .D
   

 %#'#;

";508=-40
2
 ##$ F #&*##.#)#+#) ##  #
 645536M.
      


      6!  
  

 


 %#'&)#
2"5/<#"419=0-59
   ##+, 
##@ #.
+  
#"698896M!   
      
  %#


 9,888844
   ##+$ #$.
$ #645536M)  

 
            
  
  %#/;<=;=;-3
  #.&# #, #) (#,&#,
# 
)F
#.@6
45:=6M)-
 

   
  %#+%+#'&)#445/5148;<-5
& (#.#   #6
2 (#&645:<6M*
" (  
! 
  B
   
+
   %#)-8##-+##;
=48
+, 
#"#@ #.\
   #698896M!   
    
 
    ) 
%#&)#
'%+#'9==/9919=3=-
:5
Page 24
hidden

 








































































































+ (#,*#+ #$##"#, 
 #"##)
)

#6
45586M.  
   
   
 -

  

 %#2#
4+)D)#
4:90;-3:
"  #.+# ( #&
2 #6988;6M+ -     
   
  
 %#'&)#
2#
;
38/:130:-30
#,&# #.#+  ##'
## #,
)  
#6
455=6M*       
 . -   %6%+#;3/=144;=-34

 B   6988;6'+
#-3
"*
4+6@   
 B   

Page 30
hidden

 







































































































 

)
  #6)6# #6@6#G   #
,66/45=:16.    

   
 
   a
( 
# 
 #
 6
2"#+);
! #00-
386
 
    *>


 
+
 / 
1#<   <  6
 
"    ;8   6! 
    4=
  
# F  F 
 
# 
 ,)+-!!! #
  
    6
 
!   / 1 @
4/  1
 
 
  

  # 

    
 
 J@
9

 
  
  


  # 
    
 

 J@
;
  
 #

 >
 
   J
@
<
 G 
 
 #
 >
 

   6E  
 


    #
 # 

  # 
 #
 
#

 
    6
+ 
 
     
  
   6+ >



 


 
   # 
 


 
  
6  
    

  #

        
 
+  
  
,
   #   

   6
 
E 
  
'H.
 
B


 
$ 
/ 



1# 

 / 1 / -


D
    
 1#

 /  
Page 32
hidden

 







































































































 

)
 
#6&6# 
& #+6.6# #*6#
 (#66#G  #B6/455=16* 
  
    
    
  
   
 
  6
'#

)!/;1#
4<3-404
 
    ! 


 
+
 "     
 

>  / O951 

/ O;416
    


( 
  6'   
         6
B
   


  6
 
"    "   
 
 
  
/.1    6.
  
 
  
    
/*)1  9=4 
#
   >  
  #

      6
,+., 
  F 


 
 
 
  

 
   6"   



 ,+., 

>D
 >

6
 
!   / 1 >  
 

 >  

    6
  
 

  

  F  #  >  #

   / ( #  #
 1#
     #

  62
/
1
  

  
  6     


  6 
  
 
 
   
 
 
  6B 
 
/1

    .#

 #
   6
 
    
 


#   #
6!
     
 
      # 

 

# 
   
 6
      >
 
Page 33
hidden

 







































































































 
  > 6"    
 

    6
   
 


 
    
    6"   

      
 
   62
 (  

    

 
 

   6 


 
 .# 


,
& 
   
  6 

     
 
  #  

  
 6)
  F  088
  
    
 
   6

    
 

(     #
 

 
    
6! 


  # 

  

>   
#

 


 # 
    
># 
   
 

  6.     


  F       

    ) 6
 
+  
  
!    .
   6
    
 


#
   #
6!   
 


 

?   
6
 
E 
  
"     62
 (
  
    


6.  
   

 


 
 

6
 
B


 
 
  F   
 

 ;#3#
49  6+
 


  



  
  
 


  
  
6.  
 #

     

6 
 
 
 
   

  ( 
 
 




   
6
,    


    /,.)16   

 *)# /8-:=1


    /8-0916,.)
  8-48#8   
 
    #

48 6"  
  


 ,
  +-.L6
,
-.!+)D
   


Page 35
hidden

 







































































































 

)
   #6#G$ #.6/455=16!  
    
 

 (   6 

   
  6$
&)#
;
!#:=-=4
 
    ! 


 
+
 "   
  
9
 
9=    6'   
      
F  6
 
"    "    


 !,-48
    
    #
    #  
#

  - 
   
 3  6"   >


 
F 
   -   6)>   
 
62- > 
  6
 
!   / 1  

  
  
 
 

 ( 
   


   
 

 -




     
   

 
   


$   /45=516
"    (

 

 

 (   /,16 
  ,



    (




 
   
6 
 
    



     
>  

 
,#  (  #
  #  #  
 
4Y (,   -
 - 
   6

 

  
 
 
     
 
 

  

    (  

  ,6!   
 

     # (  

  ( 
  # 

 
   

 


(6+  #
(
  (   
  

 
 
   62 # 
Page 36
hidden

 







































































































 

 (D
      
       ;8
 #

      
 6 




 6
 
+  
  
 ( / 
 1
  

  
 

6"   

 

 (
  
 
   
6
 
E 
  
'H.
 
B


 
46  #
 
  

  F  #
    
    -   
 
 ((#
 

   -
 696
!     
 6988
 F D
   6;6!  
 
 9( 
 
 


 - 6
 
+
  
  
'
 
 


,
 
)
  !   
#      
 J
    

  

  
  


  6
*
        


  9    
   
#   
   
6    
     
 

 6
 
Page 37
hidden

 










































































































)
 #!6)6#G #6 6/45:916"  
       6.
    
 


 6&)#
'
%+#'!/31#30:-305
 
    ! 


 
+
 
   
 
  
   
 
"    .
 / 
4-401    
 
 
     
    

> 
(   


   
 

 # (  
  6
 
!   / 1    a   
a

  
    
  (  
 
 #
 D
   


6"   a  
a


 
    
      ( 

 
  
  

H   #

#
   
 6
 
+  
  
)
 
    
 ( "  
48
 6  
 
 
      
 6
 
E 
  
'H.
 
B


 
    
 

 )  
   

 /    
  16 

 
  
   
 #
 >( 
 -  6 
    
   
  
  
 6
 
Page 40
hidden

 








































































































  a 
  
 
#

  
   
 
D

#
>   
 
     




6@
)
  -
    
   
  6    
(
( 

   
  #
    8/ 
 1;/ -  
 # 
  
  

  1#




   
  
    
 

  
   6
 
+  
  
'H.
 
E 
  
)-     
 "*2

  
    
  6
B


 
.
    
  -

 


     6
"   
  6  

   
#    

# 

  

( #

  F     
  #

 
 

  

   
 6  -
  
 



  4#;#3#5#
49
    
F  6,  
 
 
  
 #
  F  #

     ( 
 
49     

  
    

    D
  
 

   6$ 
  
   

 
F  
 
  
  D
  6
 
+
  
  
'
 
 


,

)
  
      

 #    


Page 41
hidden

 








































































































 
     


 6.   

   /    ( 
  38Y 

 4
 1   
 
 
  
 

 
/O868;16#;#3#5
49  
#      
 
/O868316
 
Page 45
hidden

 









































































































)
 @ #+6#@   #6"6#G #6$6
/45::16!
   


 



 6
'&)#;)#2#
!#53=-
535
 
    *>


 
+
 ;  #    6
   




  

6
 
"    :5   6! 
   


   
   
  
   # 08 # (  
    
  6
+  O306
 
!   / 1 "   
  

/@
.1# /@
1# 



 6 
   
   
  


#
 #
#
/ 1

       6"    (

 #   
 
   62  @
.#
      D
 

 
 


    
 

6@
.
 



   
  
>      

 D
 
 6
 
+  
  
'H.
 
E 
  
"  
 
B


 
 
 #    
( 


 
 
+
  
  
'
 
Page 47
hidden

 










































































































)
 @  #26#G ((#"6)6/455516
   
  
 -  
    
    
 

 
   

  C'&)#"
+#%+! /31#9888-
9880
 
    ! 


 
+
 
   6   
  
 6B
   


   
6
 
"    *
      
 B", 4=
:8  
# 
   

  #

 
   
  #
  
# 
  #
  

#(
 
6"   
      
 
 2*E4D

 =8Y

 
62
#
    # 

 
98Y   
  
/"*22*E41     
/ 
 
  98Y
  
2*E4Z",98[1 D

6. 
  D

   98Y
  /2*E4"*21     
<88
 
 6)
 B",
   
 2*E4D

 <8Y
 =8Y


6
 
!   / 1    

 45- 
(       

 HB",#
  # # -
 #
 -   6
! 
  

 "*2

   
  
  
   B",6
  
   B",

 
    
 6B",


    

   #
 

       6

    
9-


     
  
 6
  
 
Page 50
hidden

 








































































































 
E 
  
   
  
 6,  
 
 6B 
   
   /  
 16
 
B


 
    
   
 
    
 


#
  a ( 


     

 



 6
 
+
  
  
'
 
 


,
 
)
     :363Y
 
#=363Y@
9#=:60Y
@
;#
=06<Y@
<6
   
 
      


 /O8689501#
 


     
 / 
 868016"     

 
  
    
( 
 
 
 
 

 

  /  8688916
.-
   D
#



   # 
 

      
 6
 
Page 51
hidden

 









































































































)
 @ #)6#  # 6*6#G@#626
/45=516    
     6$
&)###
;
#-!#:9;-:;5
 
    *>


 
+
  
  #4
 
   / 1
 
"    :45/;88 H<45   1').!,#
 -
     #
  

 
     6
 
!   / 1 ').!,# -
      #

  
 
       
  9 
  
 #4 
  
    6
 
+  
  
     
 
E 
  
'H.
 
B


 
)- 


 

9
(   62-
D
  
4    
 ( 



 #
       6
!  
   
  6
 
+
  
  
'
 
 


,
 
)
  !  
( 

 

( 
#
   


 #   ').!, 
 #

    
   

   ( 6
Page 53
hidden

 









































































































)
    #66#) (#,6&6#@  #*6)6#
 # 66# (#66# #6)6#
 6/45:316! 
  
  
 
  6
/#4930-493=
 
    ! 


 
+
 
   a   a# 

  

 6
 
"    ;= 
  ( 
  
   
 
 
-
 >  
     6
 
!   / 1 "    >  
 




 

 # (
 


 
 ( #


  ( 
  

 6  
 
  (  -

 

>   
 
 


   
 



6 
 

  
     
  
 
 


 


 
 
 

 


   

 
 
 6    

     6
 
+  
  
"   

 



 (
 


 
 ( 62 
   - 

 

   
 



6
 
E 
  
"   
  ( 

  

 J
>   
  


     - 

6
 
Page 54
hidden

 








































































































B


 
. 



  
  a    


  
  

 6.
    
 
   

  

    
#

 #  
   6! 
   #   
 


 



 
 
>   a
a
>  
   6
 
+
  
  
'
 
 


,
 
)
  )>   #   

  946;Y    


  460Y  
6
 
Page 57
hidden

 










































































































)
 
#6)6# (#+6@6#G"#6
/455816,   
  
 

 C. 
 6&)#0#
;!/41#39-3<6
 
    ! 


 
+
 +

     
6
  
       


# 
 D
   
    -

 


    
6
 
"    5=
  
4=   

   
  
 

J     
H   
>

6
 
!   / 1 ! 
   
 > 

-    #
 /
 
1    

     
 
  6
 
+  
  
! 
   
   

 6
 
E 
  
'H.
 
B


 

  
 

   6.
 

 
 
   ( 

#      

  #
 
 
 ( 
<8 6
 
+
  
  
'
 
 


,
 
Page 59
hidden

 









































































































)
   #.6&6# #,6 6#) (#,6&6#
,
#6 6#G)F
#.6@6/45:=16
)-
 

 
    6+
%+#'&)#!
/51#48;<-
48;5

 
    ! 


 
+
 
     9>9  
  6
'         

  6
 
"    E
    


    
#-



 
 6+ 
 

;0-30
  
 
     
 #
 
 



  
 
6
 
!   / 1      
/41 -

 
   #/91 

  #/;1   #

 
  
/<1 
-
    6)
  

 /41
/91
 


(
 
   -
 6"   
  -
 
 (
  



  

 

    
       6
)
  
 /41
/;1





  

( #

 

  

  6
 
+  
  
"    (
 -


6
"   
   



6
 
E 
  
'H.
 
Page 60
hidden

 








































































































B


 
.
     

 

 /  
 
  
 

 
  
    
  
   
 
  

  
16
    
 


/1  
6)   


      
  

#
   



  
   
      6
B
   

 


6
 
+
  
  
'
 
 


,

)
 

'   
    
   
 6#
 -
 
   


 
  


    



 
  (  J 
 
         


 


6
 
Page 62
hidden

 








































































































     
 

 
  
   
 
 
 
    

 
     


 (
 

 
 

  
H

  



  6
  
        

 9-  
       # 
   
 H  

62-
   

    
 
  
 

    a 
 6
      


@    
<    
 

    
 
  #
9<   3  
  #
  @
     6   

    

   - 
@   
6
 
+  
  
   
   
   
 

(     

 
   6
      
   
  

 (  
 

 
 

  



  6
 
E 
  
'H.
B


 
 "   a
 

 
   

 
;#3#5
49   
F  
   6
 


 

     
 

  
  ;#3#5

49- -

  
    



D

  
 

  58
 
 4-
 
6 
   
  

 . 
  "
  

  

    


   

  

6
+
    B
 
  
-
     
   / ;#3#5
49-
  1 

)&-98
  
 / 
  8-<  1#
  
Page 67
hidden

 









































































































   

  
 16  

 
 

         
 # 
     #

    #



   # 

  
D
  #)  -. 
) 
>  
 
- 6+
 
  
 -  -   

 -   62 
  #

  
 ;#3#49#

4=  6!     

  a  
 62-

      

 
 -   # 
   
   
   / 

 
   > 916
 
+
  
  
'
 
 


,
 
)
       
  
  

  -
  
 
   
    
      -
       6
 
Page 68
hidden

 







































































































 

)
 &#+6&6##+6#. #6#,#6#

#6+6#G  #66/988816.

F
 
 
 
  
 
    
 

 
   


  6"%+!
/51#
588-58=6

 
    ! 


 
+
 "   
F
 
 
   
 
 
 D

( 
  

   
 6  
 
   
    # 
 
    #


   1
 

 1
 
 648=
   
  
 
 
#
48;   

  
    

6)

   


 
    
F  


6
 
"    944   4=  
 
 
 
    
 

6*>
   

#>     




    B",
>

6
 
!   / 1    
  
 

4
   
  
  9(    
#

    
#
3-(   6 






 

   6
"    

 
     


  6"   %   

    



     
 -  
 
   6   

 -

   
 F

 
  
 "*2
 6
   

  

  6"  
  
 
   
Page 69
hidden

 









































































































    
    6"   
      / 
 "*238Y
 H  1

 

 6"     

 




   

 
    
 
 

6
 
+  
  
"   %( 
>

 
 
 

 
   


  6
 
E 
  
*
   
  
 -
  
   6
 
B


 
  
 
   a

  -
  
  (  

9(    (  

3(    B
 
 (
 
  6
"   

 ;"*2
  
   
  #
  


   
:
 6
LB&     

 )@L#

   %

    
 
6
 
 
+
  
  
'
 
 


,
 
)
     
  


  
  
 ;4H34/04Y1
 (  640H:8/94Y1  (    6
 
Page 74
hidden

 









































































































)
 & #.6@6#+ #66#.#6#
 # 6"6#G   #66/45=416
 -   ( 
     6
2"!/91#944-94=6

 
    ! 


 
+
  -      
  
 #&  #45:56
 
"    *    
 


  50 
 

54-5<

   

4<8
 

 

  /41 >

      
   
#/91    
      #/;1 
 ( 

  # 
   #    
 #/<1    
 
   
#/01

  

  #
/31  
   6
 
!   / 1 . &  /45:51
 
+  
  
'H.
 
E 
  
. &  /45:51
 
B


 
. &  /45:51
 
+
  
  
'
 
  ,
Page 75
hidden

 










































































































 
)
  . &  /45:51
 
Page 78
hidden

 







































































































 

)
 +
#&66#E
#.6@6#&
  #6,6#
  #$6#+ #)6#G*   #6
/455516"  
 
   

   
F

 
  
    6
#;
+;

4"+#-!/31#9=:-95<
 
    ! 


 
+
 "   (-
F
#  



  
  6

    

 


  
 6,
 

   #   

 


6     

   
 

     

     6  

 
   

   
   
   6
 
"    "    
4=-<5     
!,-48
     F  
 
   
 
 

6
 
!   / 1  



  


 
  6
>  

 =-   
   
    


  
6  


F
 



 #
    
 
(   6"  
 
    #



  # 
 0=   6
)  

(6
 
+  
  
" 
    
  
>    F  
 
 #

   
 
 #
     #  
      #
 
       
  

  6
 
Page 79
hidden

 








































































































E 
  
'H.
 
B


 
"  

 
 
  
 49- -

/ 
  

 
  -

  4<
 16
 
+
  
  
'
 
 


,
 
)
  '   
  


  
 

 -

    
 

 
6
 
Page 80
hidden

 









































































































)
 + (#,6*6#+ #6$6##"6#
, 
 #"6##)6#G)

#6
/455816.  
   

    -


  

 62#
4+)
D)#!#90;-93:6
 
    *>


 
+
 6"   
 
   
   /)!1
# 

 /1


 
"    980 

    
     
  
 
!   / 1  

A

 %?  

 
     
#

 
    6!   


 

F
48


  
  
 
  

  

 

     

 
   

 D
    #
  
  
 #

     
#
    


#

    
 
 6   
  

     


     
6.
(
     
#
   
  

          
     6
 
     #   %
  

  
  



    

 
(

 

   6
    
   
/3-5   #49  
     16
 
+  
  
*
  
  

 
   
 
 6     6
(    
#
   
  

 6
Page 81
hidden

 








































































































 
E 
  
*
  
  

 
 
  
 6  

  

 
(

 

   6
 
B


 
   #(    #G -


 6
 
+
  
  
'H.
 
 


"
H +

 
)
  !  
    
  
   )!   #
 
    )!   6)!
   
    

 
  
 
   /3=Y ;=YJ
U8688416
 
Page 82
hidden

 









































































































)
 '#&6'6#G)
#+6,6/455:16
,  #
 #
 
 

 

    

 
        

   6;4+)
)#-!/;1#9<0-9346

 
    *>


 
+
 6"   
  
 
 

 6
 
"    :=  
    # 
40-00#
   "
 *  #  -
 #     
    
  
  
  6
 
!   / 1 @
4/ 1   
 
    

 6@
9
   

 
 
 
   
   
   

 
  
   
  
6
"   
  
 



 
   
 (
 
  
6@
;
   
 A.
 
B  % 
      J  #
 
       
 

   


 
#  
 
  6 

   


  
>  
6
*      (
>  
   
 


  
6)


 
  @
9

 >    

6.      -
       6
 
+  
  
.
 
B  >  



  

6
 
E  E
   >  

 
Page 87
hidden

 









































































































  #
 
  
  
 #
 
   

 
 (  >
6
 
+  
  
!    6,

 
  

 
- #

   


 
 
    6*
   

  6! 

  
   
62   
 
 >
6
 
E 
  
,

 )
 

  
 

6.
  



 

 # 

 
  
3  #

 
    
 6
 
B


 
.3( # -
  
 

   
  
 6
 
+
  
  
'
 
 


,
 
)
  &  
  
 #
     

 6.  
 
 
   
  



  /O868841
 
   #   
 
 

    

-

 6
 
Page 92
hidden

 








































































































 
 


,
 
)
  @
 .
/      

 1
    
  =3Y#
/   
  
 


1

 54Y#

,/    

 


1
  
50Y6
 
    
  /U8688416
 
Page 94
hidden

 










































































































 
#
  

    
 



 
6"     


-
   
J
  ;  
 
3(   >5  6
 
+  
  


  
 


 

      
   
 6
 
 

   
   6
  
  
   
  
6
 
E 
  
  
  

 #D
 


 6
 
B


 
  

 
3
  
4     
   #  - 


 
 
>   





  6. 
 
  



  R 


  S6,
  


     
  



  
 ( 

 
3  6 
 
  3- 
   #
4
    - #9
  90Y
 #;
  08Y #<

  :0Y #0
  58Y
 
3
  488Y 6
 
+
  
  
'
 
 


,

)
 
.4 -
#    
   

58Y


     
J
=064Y
0064Y /U8688416
 
    
  3
 -
# 
 
  J:;Y
056<Y 
/')16
 
Page 95
hidden

 









































































































)
 ) (#,6#   #6#@  #*6# (#
6# #,6# #6# 6/45:016

 
      
 
     
  6/!#4980-498:6
 
    ! 


 
+
 
   #9>9  
  # 

     6
 
"    +    
>
    

 


  
>   / 
 50/ 11#
 
   #
 (  

  #

  
 
  
  
  >   
 
6
 
!   / 1 !   4A
 
   %
"       # 
    # 

-
 
 (
 6
!   9A    %#
       

  #  
    #
 
> #  
  # 


 
  
 

  (  / 
    

   
- 
 #
 
  
-

R  
 S16
 
+  
  
+    
  
 
  
  
 
  # 
     

    
 

 6
 
E 
  
.
 
   
 @"

 ( 
 6+    


 
 
  
  


 -
 ( 
 6
Page 100
hidden

 








































































































 
+
  
  
'
 
 


,
 
)
  *  >      
   
   
 
  9:
 

  
  

  

/"U8688416
*          
   
   <8
 

    

  


/"U8688416
 

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Already have an account? Sign in

Readership Statistics

1 Reader on Mendeley
by Discipline
 
by Academic Status
 
100% Post Doc
by Country
 
100% United Kingdom