Modeling of biochemical pathways: Physical interpretation of network behavior

Abstract

The development of computational models allows one to easily reveal certain behaviors of the biochemical network of interest. In this project we seek to represent the set of rate equations used to describe the dynamics of a system with a common physical model. This allows for the reduction of such complexities that can restrict the model's overall stability. Conclusions from preliminary data have shown that the model produces valid results consistent with experimental data. We also have tested the model's reliability by reversing the reaction's driving potential. It has been concluded that this modeling approach gives logical and consistent results. The next phase of this project would be to apply this approach to a larger biochemical process, such as glycolysis. © 2006 IEEE.