The draft sequence of the human and mouse genomes provides an unparalleled opportunity for understanding the genetic control of immune-cell development. Strategies can begin with a gene sequence and pursue a putative immune-system function by employing mRNA-expression profiling or creating gene knockouts in embryonic stem cells. The latter can be produced by utilising the Cre/Lox system, a tetracycline operon, a gene-trap method or chemical mutagenesis. Alternatively, mutant phenotypes (derived using the mutagen ethylnitrosourea) can be traced back to gene sequences.
CITATION STYLE
Loy, A. L., & Goodnow, C. C. (2002, April 1). Novel approaches for identifying genes regulating lymphocyte development and function. Current Opinion in Immunology. Elsevier Ltd. https://doi.org/10.1016/S0952-7915(02)00331-X
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