P247 Use of the Fitbit Charge HR to monitor physical activity, sleep and heart rate during IV therapy for pulmonary exacerbations

Abstract

Objectives: To understand how physical activity, sleep and heart rate (HR) change during IV antibiotics (IV abs) for exacerbations (PEx) and how this relates to later outcomes. Method(s): Participants in a single centre observational study of PEx response wore a Fitbit Charge HR (FCHR) during IV abs. The FCHR continuously measured physical activity, sleep parameters and HR. Patterns of change and their relation to outcomes at end of treatment (EOT), 1 and 3 months were examined by Spearman R correlation (r) and Survival analysis. Result(s): 31 participants (13M) with mean(SD)age 30(7)yrs and mean ppFEV1 61(25)% enrolled. In 24hrs, most time was spent sedentary (767 (298)mins) with mean step counts 3376(1432) in the basal/limited activity range. No exercise was performed by 61%(n = 19). Sleep was disturbed with mean time asleep 309(102)mins, time awake 29(+/-13)mins, awakenings 11 (9)(range 0-49) and most common bedtime 00:00-01:00. Significant individual and temporal variation was seen. Activity, sleep and HR showed improvement early in therapy, until day 10, then negative trajectories. Participants with greater mean sedentary mins (>=892) had significantly longer IV abs (14 vs 11 days; p = 0.045) with 25% requiring further IV abs within 30 days. Mean sedentary minutes correlated negatively (r>=-0.46; p < 0.05) but time in bed correlated positively with ppFEV1 (r >= 0.47; p < 0.05). Higher mean step counts and lower sedentary mins associated with greater ppFEV1 recovery at EOT, 1/3 months. Those with shorter mean daily distance walked (<2.48 km) had significantly longer time to next PEx (TUNE)(171 vs 75 days(HR = 0.34; p = 0.03). TUNE was similar in those achieving exercise and those who did not (140 vs 123 days(HR = 1.1; p = 0.84). Conclusion(s): A Fitbit device (FCHR) can measure activity, sleep and HR during PEx, showing significant individual and temporal variation. Activity and sleep improve early, and may regress later in IV abs. Physical activity during PEx may link to later outcomes.Copyright © 2019 European Cystic Fibrosis Society. All rights reserved