Parameter Precision in Global Analysis of Time-Resolved Spectra

Abstract

By means of simulation parameter estimation in global analysis of time resolved spectra was studied. Kinetic, spectral as well as spectrotemporal models were used to describe a system consisting of an inherent mixture of components whose concentrations change with time. With a single component the parameter precision did not differ between the different model types. With two or more components the precision decreases with a kinetic or spectral model because of overlap between concentration profiles or spectra of the components. However, with a spectrotemporal model the decrease is much less, and equals zero with zero spectral overlap. © 1997 IEEE.