The physiological responses of juvenile rainbow trout (Oncorhynchus mykiss) to lithium (as LiCl) in moderately hard freshwater (CaCO3 = 120-140 ppm, Na+ = ∼0.6 mM) were studied. The study employed a 15-day step-up exposure regime; 66 μg/L Li for the first 9 days and 528 μg/L for the next 6 days. The concentrations of plasma ions, apolipoprotein AI, total cholesterol, and fatty acids, as well as metabolic enzyme citrate synthase (CS) and Na+,K+-ATPase activities in the gill were measured. Li affected fish by exacerbated diffusive Na+ losses at the gills in the beginning of exposure and a decrease of branchial CS activity. Detrimental effects were shown in fish exposed to 528 μg Li/L. These included a reduction of gill Na+,K+-ATPase activity, possibly related to observed lower concentrations of free fatty acids and cholesterol in gill tissue. © 2007 Springer Science+Business Media, LLC.
CITATION STYLE
Tkatcheva, V., Franklin, N. M., McClelland, G. B., Smith, R. W., Holopainen, I. J., & Wood, C. M. (2007). Physiological and biochemical effects of lithium in rainbow trout. Archives of Environmental Contamination and Toxicology, 53(4), 632–638. https://doi.org/10.1007/s00244-006-0173-5
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