Polymer translocation through a nanopore under a pulling force

Abstract

We investigate polymer translocation through a nanopore under a pulling force using Langevin dynamics simulations. We concentrate on the influence of the chain length N and the pulling force F on the translocation time τ. The distribution of τ is symmetric and narrow for strong F. We find that τ∼ N2 and translocation velocity v∼ N-1 for both moderate and strong F. For infinitely wide pores, three regimes are observed for τ as a function of F. With increasing F, τ is independent of F for weak F, and then τ∼ F-2+ ν-1 for moderate F, where ν is the Flory exponent, which finally crosses over to τ∼ F-1 for strong force. For narrow pores, even for moderate force τ∼ F-1. Finally, the waiting time, for monomer s and monomer s+1 to exit the pore, has a maximum for s close to the end of the chain, in contrast to the case where the polymer is driven by an external force within the pore. © 2007 The American Physical Society.