Preparation of bicyclic compounds as modulators of androgen receptor function.

Abstract

Bicyclic compds. of formula I [R1 = H, alkyl, arylalkyl, etc.; R2, R3 = H, alkyl, (substituted) OH, halo, (substituted) NH2, etc.; R4-R7 = H, alkyl, cycloalkyl, arylalkyl, aryl, etc.; R4R5, R6R7 = O, S, NH, CH2, etc.; R8, R9 = H, alkyl, (substituted) OH, (substituted) NH2, etc.; X = (CH2)n; n = 1-2] are prepd. as modulators of androgen receptor function. Further provided are methods of using such compds. for the treatment of nuclear hormone receptor-assocd. conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compns. contg. such compds. and processes for prepg. some of the compds. of the invention. Thus, II was prepd. from 4-isocyanato-5,6,7,8-tetrahydronaphthalene-1-carbonitrile and Me (2S,3R)-3-hydroxy-2-pyrrolidinecarboxylate (prepns. given). [on SciFinder(R)]