Preparation and evaluation of bioerodible buccal tablets containing clotrimazole

Abstract

Buccoadhesive erodible tablets for local delivery of clotrimazole (CLT) to the oral cavity were developed using different bio-adhesive polymers along with soluble excipients like mannitol and polyethylene glycol-6000. An apparatus simulating the in vivo conditions of the mouth was designed in order to assess in vitro, the bio-adhesive performance and release characteristics of these tablets. The in vitro adhesion time and release characteristics were found to be a function of the type of polymer and also the total composition of the tablets. In vivo evaluation of placebo tablets in healthy human volunteers indicated a linear and positive correlation between the in vitro and in vivo adhesion time.