Abstract
Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was developed through a cyclization of the C-2 position on the pyrrole N-1 nitrogen. The resulting pyrrolo[1,2-a]pyrazinones are potent and noncompetitive antagonists.
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Micheli, F., Cavanni, P., Di Fabio, R., Marchioro, C., Donati, D., Faedo, S., … Tranquillini, M. E. (2006). From pyrroles to pyrrolo[1,2-a]pyrazinones: A new class of mGluR1 antagonists. Bioorganic and Medicinal Chemistry Letters, 16(5), 1342–1345. https://doi.org/10.1016/j.bmcl.2005.11.049
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