Recent Advances in Augmented Reality

Abstract

The effective and high yielding synthesis of poly-functionalized pyrimidines, using multicomponent reactions (MCRs), is imperative in organic and medicinal chemis- try. The classic Biginelli reaction is a typically one-pot three-component cyclocondensa- tion reaction involving an aldehyde, a β-ketoester and urea, resulting in the construction of multi-functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs). In recent years, other active methylene compounds, various derivatives of urea and diversely substituted alde- hydes have also been used, resulting in the preparation of a new series of various novel dihydropyrimidinones via the Biginelli-Type Reactions (BTRs) or modified Biginelli re- actions (MBRs). In this review, we try to underscore the recent advances in BTRs or MBRs