The structure of the homeodomain and its functional implications
Trends in Genetics (1990)
- ISSN: 01689525
- PubMed: 1980756
Available from www.ncbi.nlm.nih.gov
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Abstract
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
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