Sub-2 μm Silica Particles in Chiral Separation

Abstract

For decades, the race for the shortest chromatogram with the best resolution and separation efficiency has been the focus of researchers and manufacturers. Considerable advancement has been attained in the field of separation science with the widespread applications and outstanding performance of nanomaterials. According to the van Deemter equation, sub-2 micron particles employed in a conventional HPLC short column should subsequently result in analysis time reduction and efficiency improvements without the drawbacks of high pressure associated with sub-2 micron particles. This chapter provides comprehensive discussion about the applications of the new sub 2 microns silica particles in chiral separation of racemates.