The synthesis and structure revision of NSC-134754

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Abstract

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.

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Hickin, J. A., Ahmed, A., Fucke, K., Ashcroft, M., & Jones, K. (2014). The synthesis and structure revision of NSC-134754. Chemical Communications, 50(10), 1238–1240. https://doi.org/10.1039/c3cc48189a

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