Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Abstract

Thyroid hormone induces browning of white fat, but it is unclear whether this contributes to thermogenesis. Here, Johann et al. show that thyroid-hormone-induced beige fat is metabolically inactive due to lack of central stimulation and that the metabolic and thermogenic effects of the hormone are independent of UCP1.