The triplet genetic code had a doublet predecessor

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Abstract

Information theoretic analysis of genetic languages indicates that the naturally occurring 20 amino acids and the triplet genetic code arose by duplication of 10 amino acids of class-II and a doublet genetic code having codons NNY and anticodons GNN←. Evidence for this scenario is presented based on the properties of aminoacyl-tRNA synthetases, amino acids and nucleotide bases. © 2004 Elsevier Ltd. All rights reserved.

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Patel, A. (2005). The triplet genetic code had a doublet predecessor. Journal of Theoretical Biology, 233(4), 527–532. https://doi.org/10.1016/j.jtbi.2004.10.029

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