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Web services for DNA sequence analysis

by D Shestakov, T Salakoski
Database and Expert Systems Applications, 2005. Proceedings. Sixteenth International Workshop on ()

Abstract

The standardized interface to sequence analysis tools is highly desirable\nto integrate bioinformatics applications. Currently existing software\npackages and programming toolkits (BioPerl, BioJava, etc.) used by\nbioinformaticians for DNA sequence analysis have limited support\nfor exchanging and reusing data. To solve these issues, we propose\nthe Web services approach and discuss how to apply the Web services\ntechnology for nucleotide sequence analysis workflow. In this work,\nwe present a program-friendly interface to DNA sequence analysis\ntools using Web services. All data including query requests to the\nWeb services are managed in XML-formats. The Web services responsible\nfor statistical analysis provide an interface to the R statistical\nenvironment and can perform analysis using several statistical methods\n(including correspondence analysis and principal component analysis).\nOutput of the Web services is in XML-format and, thus, can be stored\nin local XML databases.

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