L-α-aminoadipate reduces glutamate release from brain tissue exposed to combined oxygen and glucose deprivation

Abstract

The effect of the glutamate analogue L-α-aminoadipate (αAA) on the release of glutamate and γ-amino-butyric acid (GABA) from rat hippocampal slices was investigated in vitro. Oxygen/glucose deprivation caused a large release of glutamate and GABA. αAA added during energy deprivation reduced the glutamate release in a dose-dependent manner (56% reduction at 5 mM), whereas GABA release was unchanged. We speculate that ischemic glutamate release from the brain is mediated by a low affinity transport mechanism that is blocked by αAA.