Palbociclib plus an aromatase inhibitor as first-line therapy for metastatic breast cancer in US clinical practices: Real-world progression-free survival analysis

Abstract

A 63-year-old female with stage {IE} diffuse large B-cell lymphoma developed reversible posterior leukoencephalopathy syndrome ({RPLS)} following {CHOP} chemotherapy, with typical clinical and radiological findings. {RPLS} is a rare neurological syndrome characterised by visual disturbances, seizures, headaches and altered conscious level which has been associated with malignant hypertension, pre-eclampsia and some drugs, including ciclosporin. It has not been previously reported following {CHOP} chemotherapy. Alternative treatment should be considered for patients who develop this rare complication.