Pd/C-Mediated synthesis of indoles in water

Abstract

We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,s 5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction. © 2009 Layek et al; licensee Beilstein-Institut.