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Methotrexate for high-grade osteosarcoma in children and young adults

  • van Dalen E
  • van As J
  • de Camargo B
Cochrane Database of Systematic Reviews (2011) 2019(4)
DOI: 10.1002/14651858.cd006325.pub3
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Abstract

The majority of the currently used treatment protocols for osteosarcoma are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has not been unambiguously proven.

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van Dalen, E. C., van As, J. W., & de Camargo, B. (2011). Methotrexate for high-grade osteosarcoma in children and young adults. Cochrane Database of Systematic Reviews, 2019(4). https://doi.org/10.1002/14651858.cd006325.pub3

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