Synthesis, characterization and antibacterial activity of carbamate derivatives of isatin

Abstract

In search of novel antibacterial agent, a series of new isatin derivatives(3a-d)have been synthesized by condensation isatin(2,3-indolinendione) with piperidine(hexahydropyridine), hydrazine hydrate and Boc-amino acids respectively. Compounds synthesized have been characterized by IR spectroscopy and elemental analysis. In addition, the in vitro antibacterial properties have been tested against E. coli, P. aeruginosa, and Bacillus cereus, S. aureus by employing the well diffusion technique. A majority of the synthesized compounds were showing good antibacterial activity and from comparisons of the compounds, where 3d has been determined to be the most active compound.