CURCUMA LONGA

Abstract

Objectives: To analyze the hepatoprotective effects of Curcuma longa (CL)against carbon tetrachloride (CCl4) induced chemical injury in experimental rats. Study Design:Experimental study. Setting: Indus Medical College in collaboration with Animal house of SindhAgriculture University Tando Jam. Period: March 2016 to August 2016. Methodology: Sixtyadult male rats were selected according to inclusion and exclusion criteria. Rats were dividedrandomly into 3 groups – as group A. controls, group B – received CCl4 and group C- receivedCCl4 + CL orally. Blood samples were taken after 4 weeks of therapy by cardiac puncture.5μ thick liver tissue sections were stained for light microscopy examination. Analysis of datawas performed on Statistix 9.0 (USA) at statistical significance of p-value ≤ 0.5. Results: Livercell biochemical markers of injury and histopathological examination show the Curcuma longais effective against carbon tetrachloride induced liver injury (P <0.05). Liver histology wasimproved by the curcuma longa therapy. Conclusion: Liver aminotransferase and histologywere improved significantly by the curcuma longa therapy in carbon tetrachloride induced liverinjury.