Proinflammatory cytokine polarization in type 2 diabetes

Abstract

Subclinical inflammatory reaction is associated with non-insulin dependent diabetes. therefore, the aim of the present study is to describe the effect of the three cytokines: interferon γ (iFN-γ), interleukin (il)-4 and il-5 on the development of type 2 diabetes (t2D). Forty-five volunteers (after their permission) were participated in this work; according to their clinical examination and laboratory investigations (fasting blood sugar, 2 hours postprandial, hba1c and lipid profile), they were divided into thirteen control (non-diabetic) (five females and eight males) and thirty-two diabetic patients (twenty-one females and eleven males). thereafter, their sera were evaluated for C-reactive protein (CrP), iFN-γ, il-4 and il-5. the results revealed an increasing trend of CrP and a significant increase of iFN-γ in diabetic patients with no sex difference. a positive correlation between iFN-γ and both il-4 and il-5 in control, and a positive correlation between il-4 and il-5 in diabetic patients had been visualized. these results denoted that there may be an association of the pro-inflammatory cytokines in the etiology of diabetes mellitus type 2.