Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids

Abstract

Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital im-portance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydroura-cils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihy-drouracils. Hence, under mild conditions, 3‐chloroperbenzoic acid was used to cleave the carbon– sulfur bond of the Biginelli hybrids 5,6‐dihydropyrimidin‐4(3H)‐ones. This approach led to thirteen novel dihydrouracils synthesized in moderate‐to‐high yields (32–99%).