Journal ArticleOPEN ACCESS

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

  • Kumari N
  • Ammosova T
  • Diaz S
  • et al.
Blood Advances (2016) 1(3) 170-183
DOI: 10.1182/bloodadvances.2016000745
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Abstract

Ferroportin reduces intracellular iron, inhibits CDK2 and suppresses SAMHD1 phosphorylation thus inhibiting HIV-1 RT. Ferroportin expression leads to overexpression of IKBα and inhibition of HIV-1 transcription.

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Kumari, N., Ammosova, T., Diaz, S., Lin, X., Niu, X., Ivanov, A., … Nekhai, S. (2016). Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease. Blood Advances, 1(3), 170–183. https://doi.org/10.1182/bloodadvances.2016000745

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