The chemical compounds of flacourtia rukam leaves and their inhibition of anggiotensin-converting enzyme (Ace) activity

Abstract

Flacourtia rukam is a popular plant to treat hypertension, especially the Musi Banyuasin of South Sumatera, Indonesia. Isolation and identification of chemical compounds from F. rukam leaves and evaluation of their effects on antihypertensive activity have been conducted. Isolation of chemical compounds using chromatographic methods and identification using spectroscopic methods were compared with the reported data. The drug’s effects on antihypertension were determined using the angiotensin-converting enzyme (ACE) inhibitory method. Two compounds have been isolated from the leaves of F. rukam and identified as apigenin (1, 20 mg) and lupeol (2, 17 mg). Lupeol (2) was first reported and isolated from the leaves of F. rukam. These compounds were demonstrated to be effective in treating antihypertension with 15.12 ± 0.72 μg/mL for apigenin and IC50 656.51 ± 1.55 μg/mL for lupeol. It can be concluded that F. rukam leaves are a potential ACE inhibitor that can be explored further as an effective antihypertensive agent.