Liposomes: Novel Drug Delivery Approach for Targeting Parkinson’s Disease

Abstract

GEEN PDF ($65) MAAR ABSTRACT HANDIG VOOR ARTIKEL Parkinson's disease is one of the most severe progressive neurodegenerative diseases which have a mortifying effect on the health of almost hundreds of millions of people around the globe. The neural cells producing dopamine in the substantia nigra of the brain die out which leads to symptoms like hypokinesia, rigidity, bradykinesia and rest tremor.Parkinsonism cannot be cured but the symptoms can be reduced with the intervention of medicinal drugs, surgical treatments and physical therapies. Delivering drugs to the brain for treating Parkinson's disease is very challenging, the blood brain barrier act as a highly selective semi permeable barrier which refrains the drug from reaching the brain. Conventional drug delivery systems used for Parkinson's disease does not easily cross the blood barrier and further leads to a number of side effects. Recent advancements in drug delivery technologies have facilitated the drug delivery to the brain without flooding the blood stream and by directly targeting the neurons.In the era of Nanotherapeutics, liposomes can be an efficient drug delivery option for brain targeting.Liposomes can facilitate the passage of drugs across the blood brain barrier, enhances the efficacy of the drugs and minimises the side effects related to it. The review aims at providing a broad updated view of the liposomes, which can be used for targetingParkinson's disease.