Functional and morphological evolution of remnant pancreas after resection for pancreatic adenocarcinoma

Abstract

Functional and morphological evolution of remnant pancreas after resection for pancreatic adenocarcinoma is investigated. The medical records of 45 patients who had undergone radical resection for pancreatic adenocarcinoma from March 2010 to September 2013 were reviewed retrospectively. There were 34 patients in the pancreaticoduodenectomy (PD) group and 10 patients in the distal pancreatectomy (DP) group. One patient received total pancreatectomy. The endocrine function was measured using the glucose tolerance index (GTI), which was derived by dividing daily maximum serum glucose fluctuation by daily minimum glucose. Remnant pancreas volume (RPV) was estimated by considering pancreas body and tail as a column, and head as an ellipsoid, respectively. The pancreatic atrophic index (PAI)was defined as the ratio of pancreatic ductwidth to total pancreas width. Representative indices of each patient were compared before and after resection up to 2 years postoperatively. The area under receiver operating characteristic curve of GTI for diagnosing DMwas 0.823 (95% confidence interval, 0.699-0.948, P