Pantoprazole: An unusual suspect in a patient with fever

Abstract

Drugs can cause fever of unknown origin. Drug fever is a diagnosis of exclusion and can lead to unnecessary investigations and prolonged hospitalization. Any drug can be responsible. Here, we describe the case of a woman admitted because of acute hepatitis. Pantoprazole was started for stress ulcer prophylaxis when she was admitted to the ICU. Fever developed a few days later and an extensive diagnostic workup was negative. Fever remitted after pantoprazole discontinuation and the diagnosis of drug fever was established.