HER2 in Gastric Cancer: A Comprehensive Analysis Combining Meta-Analysis and DCE-MRI Radiomics

Abstract

Objective: Advanced gastric cancer (AGC) is a severe malignant tumor, and overexpression of HER2/ERBB2 may play a crucial role in its development. The purpose of this study is to investigate the overexpression of HER2/ERBB2 in gastric cancer through a meta-analysis and examine its relationship with perfusion parameters using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technology. Methods: We conducted an extensive literature search and collected relevant studies for the meta-analysis. We used a random-effects model and assigned weights using the “inverse variance” method. Additionally, we included 95 AGC patients diagnosed pathologically between April 2018 and October 2021. They all underwent DCE-MRI scans, and the data were subsequently analyzed using the Omni kinetic software. HER2 expression was assessed using immunohistochemistry. Results: The meta-analysis revealed an overall odds ratio (OR) of.21 for HER2/ERBB2 overexpression in gastric cancer, with a 95% confidence interval of [.14,.30]. DCE-MRI results showed a significant association between high HER2 expression and poor tumor differentiation (P