Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway

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Abstract

An important contribution of cancer associated fibroblasts (CAFs) in regulating chemoresistance has been reported. Here the authors investigate the impact of chemotherapy on CAF subsets in patients with high-grade serous ovarian cancer, suggesting that residual ANTXR1+ myofibroblasts are associated with inhibition of anti-tumor immunity.

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Licaj, M., Mhaidly, R., Kieffer, Y., Croizer, H., Bonneau, C., Meng, A., … Mechta-Grigoriou, F. (2024). Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45595-3

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