Comparative in-vivo evaluation of anti-cancer drugs loaded nanospheres

Abstract

Objectives: objective of present research was to formulate and evaluate nanospheres of selected anticancer drugs, viz., Capecitabine (CPN), Tamoxifen (TAM) and Doxorubicin (DXO). The adverse effects associated with anticancer drugs which include are bone-marrow depression, cardio toxicity, diarrhoea, nausea and vomiting, stomatitis and dermatitis. Materials and Methods: Drug loaded nanospheres of polycaprolactone-chitosan in various drug: polymer ratios, cross linked with Tripolyphosphate were prepared by double emulsion solvent evaporation and solvent diffusion methods. Male white New Zeeland Rabbits(weighing about 2500 gm) were selected as the animalmodel. The rabbits selected for the study had no medicationfor two weeks prior to the study. Results and Discussion: The parameters like AUC(0-24) of DXO nanospheres 2362.0 ng.h/mL, whereas DXO pure drug was 1956.5 ng.h/mL. AUC (0-24) of TAM nanospheres 5646.00 ng.h/mL. Whereas TAM unadulterated medication was 4786.30ng.h/mL. AUC (0-24) of CPN nanospheres 4927.40 ng.h/mL. Whereas CPN pure drug was 4027.5ng.h/mL. Conclusion: In vivo results showed a significant increase in the bioavailability of drugs from DXO6, CPN6 and TAM6 nanospheres when compared to those of the standard drugs. This enhanced bioavailability could be helpful in reducing the dose of DXO, CPN and TAM and also reduce their toxicities. This enhanced bioavailability could be helpful in reducing the dose and also reduce the toxicities of the selected drugs.