Cholinesterasehemmer. Stellenwert in anästhesie, intensivmedizin, notfallmedizin und schmerztherapie

Abstract

Many drugs currently used in anaesthesia practice modify cholinergic transmission, therefore, acetylcholinesterase inhibitors are a part of anaesthetic pharmacology. Besides its well established use in the antagonism of neuromuscular blockades and the therapy of central anticholinergic syndrome (CAS), results of controlled studies and case reports suggest other favourable indications such as the prevention and therapy of postanaesthetic shivering and the treatment of various types of intoxication and delirium. Cholinesterase inhibitors may also have analgesic properties. This review summarises the pharmacological and physiological backround and describes favourable indications of this class of drugs. © Springer Medizin Verlag 2005.