Cytogenetic Aspects Of Miscarriage

Abstract

Petrović B. and M. Komnenić Radovanović (2021). Cytogenetic aspects of miscarriage. - Genetika, Vol 53, No.2, 663-670. Chromosomal aberrations account for approximately 50% of fetal losses prior to the 15th week of gestation. The aim of this study was to determine the differences in frequencies and distribution of chromosomal aberrations in sporadic and habitual abortions. During a seven year period (2007.-2014.), we have analyzed 380 samples of chorionic villi after missed abortion in the Clinic for gynecology and obstetrics, Clinical center of Serbia. After first misscariage we analyzed 268 samples, and after habitual abortions 112 samples. For statistical analysis, we used χ, ² test. Karyotype analysis revealed chromosomal aberrations in 22,4% (85/380) of all samples. In the group after first abortion, we found an aberrant karyotype in 15,7% (42/268) of cases. In the group with habitual abortions, chromosomal aberrations were detected in 38,4% (43/112) of cases. Statistical analysis showed significant difference between these two groups, χ ² =11,34> χ ² (1 I 0,05)=3,841i p<0,05. The distribution of chromosomal aberrations was similar in both groups. Also, in both groups, numerical chromosomal aberrations were the most common. The identification of cytogenetic causes is an important component in miscarriage etiology investigation, and it is recommended in order to improve genetic counseling of an involved couple.