Beta 1 -Adrenergic Receptor Regulation Revisited

Abstract

The actions and regulation of cardiomyocyte β1ARs (β1 adrenergic receptors) differ in several respects from the properties described for the prototypical β2AR subtype; a mechanism to explain the unique properties of the β1AR subtype has never been obvious. This viewpoint summarizes recent studies that identify a novel signaling paradigm for the β1AR, implicating the N terminus as a molecular determinant of β1AR responsiveness.