LIQUISOLID TECHNIQUE: AN APPROACH FOR ENHANCEMENT OF SOLUBILITY

Abstract

Slow dissolution rate of poorly water soluble drugs faces major challenge in the drug development and delivery processes. Improving aqueous solubility and slow dissolution of BCS Class II and Class IV drugs have been explored extensively. Of the available approaches, liquisolid compact technology is the most latest and novel approach for overcoming the trouble of inadequate solubility of the poorly soluble drugs. The liquisolid technology as described by Spireas is a liquid which is transformed into a free flowing, readily compressible and apparently dry powder by simple physical blending with selected excipients like the carrier and coating material. The liquid portion, which is a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicles, is incorporated into the porous carrier material. Water-miscible organic solvent systems with high boiling point like propylene glycol, polyethylene glycols, or glycerine are the suitable liquid vehicles. The drug is present in the liquid medicament as solubilized or molecularly dispersed state, so the dissolution is enhanced due to increased surface area, wetting area and also increases bioavailability.